Recurrent Non Immune Hydrops Fetalis with Polyhydramnios: a Case Report

Recurrent non-immune fetal hydrops (NIH) has been reported in the literature but it’s a very rare entity. It has been postulated to be related to a recessive gene. We report a case of recurrent non immune fetal hydrops in a multigravida with no medical history of note. She presented in her current pregnancy with a significant history of having 2(out of 3) previous pregnancies affected by hydrops. All the affected pregnancies resulted in mid-trimester pregnancy termination following diagnosis in the second trimester. Her most recent pregnancy was unaffected. We discuss the possible differential diagnoses and the likelihood of autosomal recessive metabolic diseases being the etiological factor. Rare causes of fetal hydrops need to be excluded in cases of recurrent non-immune hydrops with no obvious etiology following routine investigations.